REGIOSELECTIVITY OF ALKYLATION OF 3-SUBSTITUTED 5-AMINO-1,2,4-THIADIAZOLES

Authors

  • М. Хакимов Acad. S. Yunusov Institute of Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent 700170
  • Р. Ф. Амбарцумова Acad. S. Yunusov Institute of Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent 700170
  • Б. Ташходжаев Acad. S. Yunusov Institute of Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent 700170
  • М. Ю. Антипин A. N. Nesmeyanov Institute of Organoelement Compounds, Moscow 117813
  • Х. М. Шахидоятов Acad. S. Yunusov Institute of Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent 700170

Keywords:

4-alkyl-5-imino-4,5-dihydro-1,2,4-thiadiazoles, 5-amino-1,2,4-thiadiazoles, tetrahydropyrimido[2,1-b]-1,2,4-thiadiazoles, ethylene chlorohydrin, epichlorohydrin, X-ray diffraction

Abstract

We have synthesized 3-substituted 4-alkyl-5-imino-4,5-dihydro-1,2,4-thiadiazoles by reaction of 3‑alkyl(benzyl)thio-5-amino-1,2,4-thiadiazoles with methyl iodide or ethylene chlorohydrin. In the reaction with epichlorohydrin, addition of an oxirane molecule occurs with formation of tetrahydropyrimido[2,1-b]-1,2,4-thiadiazoles.

How to Cite
Khakimov, M.; Ambartsumova, R. F.; Tashkhodzhaev, B.; Antipin, M. Yu.; Shakhidoyatov, Kh. M. Chem. Heterocycl. Compd. 2001, 37, 1005. [Khim. Geterotsikl. Soedin. 2001, 1095.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1012795819528

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Published

2001-08-25

Issue

No. 8 (2001)

Section

Original Papers