SYNTHESIS AND ALKYLATION OF 4-(2-CHLOROPHENYL)-3-CYANO-6-HYDROXY-5-(2-THIENOYL)-6-TRIFLUOROMETHYLPIPERIDIN-2-THIONE

Authors

  • С. Г. Кривоколыско Taras Shevchenko Lugansk State Pedagogical University, Lugansk 34801
  • В. Д. Дяченко Taras Shevchenko Lugansk State Pedagogical University, Lugansk 34801
  • Э. Б. Русанов Institute of Organic Chemistry, Ukraine National Academy of Sciences, Kiev 253660
  • В. П. Литвинов N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 117913

Keywords:

piperidinthione, tetrahydropyridine, 2-thienoyltrifluoroacetone, 2-chlorobenzaldehyde, 2 chlorophenylmethylenecyanothioacetamide, cyanothioacetamide, alkylation, X-ray crystallography

Abstract

4-(2-Chlorophenyl)-3-cyano-6-hydroxy-5-(2-thienoyl)-6-trifluoromethylpiperidin-2-thione, which was used for the synthesis of 2-allylthio-4-(2-chlorophenyl)-3-cyano-6-hydroxy-5-(2-thienoyl)-6-trifluoromethyl-1,4,5,6-tetrahydropyridine, was obtained by the reaction of 2-thienoyltrifluoroacetone with 2-chlorophenylphenylmethylenecyanothioacetamide or with a mixture of 2-chlorobenzaldehyde and cyanothioacetamide in the presence of N-methylmorpholine. The molecular and crystal structure of the piperidinthione have been established by X-ray crystallography.

How to Cite
Krivokolysko, S. G.; Dyachenko, V. D.; Rusanov, E. B.; Litvinov, V. P. Chem. Heterocycl. Compd. 2001, 37, 987. [Khim. Geterotsikl. Soedin. 2001, 1076.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1012739601781

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Published

2001-08-25

Issue

No. 8 (2001)

Section

Original Papers