5-CHLORO-4-[(THIAZOLIDIN-5-YLIDENE)METHYL]PYRROLE-3-CARBOXYLATES AND CARBOXYLIC ACIDS: SYNTHESIS, RECYCLING, AND ANTIMICROBIAL ACTIVITY

Authors

  • Alina M. Grozav Bukovinian State Medical University, 2 Teatral'na Sq., Chernivtsi 58000 https://orcid.org/0000-0001-9821-0695
  • Mariana Z. Fedoriv Institute of Organic Chemistry of National Academy of Sciences of Ukraine, 5 Akademika Kukharya St., Kyiv 02094
  • Vitaliy O. Chornous Bukovinian State Medical University, 2 Teatral'na Sq., Chernivtsi 58000
  • Sergiy V. Kemskyi Institute of Organic Chemistry of National Academy of Sciences of Ukraine, 5 Akademika Kukharya St., Kyiv 02094
  • Nina D. Yakovychuk Bukovinian State Medical University, 2 Teatral'na Sq., Chernivtsi 58000
  • Oleksandr S. Liavynets Bukovinian State Medical University, 2 Teatral'na Sq., Chernivtsi 58000
  • Mykhailo V. Vovk Institute of Organic Chemistry of National Academy of Sciences of Ukraine, 5 Akademika Kukharya St., Kyiv 02094

Keywords:

5-chloro-4-formylpyrrole-3-carboxylates, 5-chloro-4-formylpyrrole-3-carboxylic acids, 5-chloro-4-[(thiazolidin-5-ylidene)methyl]- pyrrole-3-carboxylates, 5-chloro-4-[(thiazolidin-5-ylidene)methyl]pyrrole-3-carboxylic acids, thieno[2,3-b]pyrrole-2,4-dicarboxylic acids, alkaline hydrolysis, antimicrobial activity, recycling

Abstract

5-Chloro-4-formylpyrrole-3-carboxylates and carboxylic acids can smoothly interact with thiazolidin-4-ones and form 5-chloro-4-[(thiazolidin-5-ylidene)methyl]pyrrole-3-carboxylates and carboxylic acids, respectively, which can further be transformed into thieno[2,3-b]pyrrole-2,4-dicarboxylic acids through the alkaline hydrolysis. Moderate antimicrobial activity has been registered in 5-chloro-4-[(thiazolidin-5-ylidene)methyl]pyrrole-3-carboxylates and the corresponding carboxylic acids.

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Published

2026-02-24

Issue

Vol. 61 No. 9/10 (2025): Modern catalytic approaches for the assembly and functionalization of heterocyclic compounds

Section

Original Papers