Synthesis and reactions of esters of 3-cyano-2-oxo-5,6-tri(tetra)methylene-1,2-dihydroisonicotinic and 2-amino-3-ethoxycarbonyl-5,6-tri(tetra)methyleneisonicotinic acids

Abstract

Esters of 3-cyano-2-oxo-5,6-tri(tetra)methylene-1,2-dihydroisonicotinic and 2-amino-3-ethoxycarbonyl-5,6-tri(tetra)methyleneisorticotinic acids have been obtained by the reaction of 2-oxocyclopentyl(hexyl)glyoxylic acid esters with malonic acid derivatives. Boiling the esters containing a tetramethylene ring with 75% sulfuric acid gave hydrolysis of the ester and cyano groups to carboxyl with subsequent decarboxylation at the 3 position and the formation of 2-oxo-5,6-tetramethylene-1,2-dihydroisonicotinic acid (2-oxo-1,2,5,6,7,8-hexahydroquinoline-4-carboxylic acid).

How to Cite
Smirnova, T. A.; Gavrilov, M. Yu. Chem. Heterocycl. Compd. 1996, 32, 319. [Khim. Geterotsikl. Soedin. 1996, 370.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01169251