Photoinduced N-β-hydroxyalkylation of tropan derivatives

Authors

  • Л. М. Косточка Scientific-Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow 125315
  • А. П. Сколдинов Scientific-Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow 125315
  • B. П. Лезина Scientific-Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow 125315

Abstract

The photooxidation of tropan derivatives by ketones was studied; the targeting of the reaction to the N-CH3 group with the formation of N-alkylation products and bis-tropan derivatives was demonstrated. The presence of two diastereomers in salts of N-alkyl derivatives of tropan was detected by PMR spectroscopy. An alternative method of synthesis of difficult-to-obtain amino alcohols was proposed.

How to Cite
Kostochka, L. M.; Skoldinov, A. P.; Lezina, V. P. Chem. Heterocycl. Compd. 1995, 31, 153. [Khim. Geterotsikl. Soedin. 1995, 179.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01169671

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Published

1995-02-25

Issue

No. 2 (1995)

Section

Original Papers