Heterogeneous catalysts in the alkylation of imidazoles
Abstract
The reaction of imidazoles with alcohols at 300–400°C was studied in the presence of heterogeneous γ-Al2O3 catalysts and Y zeolites. The major reaction was found to be N-alkylation. This reaction is accompanied by C-alkylation on γ-Al2O3 while the selectivity relative to N-alkylation is close to 100% on zeolite catalysts. The greatest activity with 100% selectivity was found for H zeolite. The alkylation of methanol and ethanol by 2-methylimidazole at 310–320°C gave 1,2-dimethylimidazole in 100% yield and 1-ethyl-2-methylimidazole in 90% yield respectively. The reaction of methanol and imidazole gave 1-methylimidazole in 99% yield. This catalyst displays high stability and capacity for oxidative regeneration.
How to Cite
Gitis, K. M.; Neumoeva, G. E.; Isagulyants, G. V. Chem. Heterocycl. Compd. 1994, 30, 547. [Khim. Geterotsikl. Soedin. 1994, 624.]
For this article in the English edition, see DOI https://doi.org/10.1007/BF01169831
