Synthesis of N-tetrahydropyranyl-S-methylmethioninesulfonium salts

Authors

  • C. А. Васильева Bashkir State University, 450074, Ufa
  • С. А. Санкина Bashkir State University, 450074, Ufa
  • М. Г. Сафаров Bashkir State University, 450074, Ufa

Abstract

D,L-Methionine reacts in alkaline medium with 4-methyl-3,4-epoxytetrahydropyran via the amino group to form, in accordance with the Krasusskii rule, an oxirane ring opening product, namely N-(4-hydroxy-4-methyl-3-tetrahydropyranyl)-D,L-methionine. N-(4-Hydroxy-4-methyl-3-tetrahydropyranyl)-S-methylmethioninesulfonium salts are synthesized in high yields by methylating the latter then treating it with organic or inorganic acids.

How to Cite
Vasil'eva, S. A.; Sankina, S. A.; Safarov, M. G. Chem. Heterocycl. Compd. 1994, 30, 523. [Khim. Geterotsikl. Soedin. 1994, 597.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01169825

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Published

1994-05-25

Issue

No. 5 (1994)

Section

Original Papers