INTRAMOLECULAR CARBONYL NITROSO ENE REACTION: RECENT DEVELOPMENTS

Abstract

Novel single-step protocols for intramolecular oxidative cyclization of unsaturated hydroxamic acids proceeding by carbonyl nitroso ene reaction were reported. The reaction can be viewed as a formal intramolecular allylic C–H amination. Simple, mild catalytic system based either on CuCl–O₂ in THF or FeCl₃–H₂O₂ in 2-propanol do not adversely affect the transient nitroso species and allow the nitroso ene reaction to take place.

Also published in Chemistry of Heterocyclic Compounds, 2012, 48 (1), pp 39-43

http://link.springer.com/article/10.1007/s10593-012-0966-6