SYNTHESIS AND INTRAMOLECULAR CYCLIZATION OF <i>N</i>-ACYL- AND <i>N</i>-ALLYL-<i>N</i>'-(2-OXO-1,2-DIHYDROPYRIDIN-3-YL)THIOUREA
DOI:
https://doi.org/10.1007/1462Keywords:
3-aminopyridin-2(1H)-ones, isothiocyanates, 1, 3-thiazines, 3-thiazolines, thioureas, intramolecular cyclizationAbstract
The reaction of 3-amino-4,6-dimethylpyridin-2(1H)-one and 3-amino-4-phenylpyridin-2-one with acyl isothiocyanates (benzoyl-, 4-bromobenzoyl-, and methacryloyl isothiocyanates) and with allyl isothiocyanate has been studied. The N-carbamothioyl methacrylamides and N-allylthioureas obtained undergo intramolecular heterocyclization reactions to give the corresponding 1,3-thiazin-4-one and 1,3-thiazoline derivatives. It was found that the starting 3-amino-4,6-dimethylpyridin-2(1H)-one shows antiradical activity but the synthesized thioureas do not.
How to Cite
Kulakov, I. V.; Nikitina, O. S.; Fisyuk, A. S.; Goncharov, D. S.; Shul'gau, Z. T.; Gulyaev, A. E. Chem. Heterocycl. Compd. 2014, 50, 670. [Khim. Geterotsikl. Soedin. 2014, 729.]
For this article in the English edition see DOI 10.1007/s10593-014-1519-y
