AMINOMETHYLATION OF 3-ARYL-7-HYDROXYCOUMARINS

Authors

  • С. П. Бондаренко Taras Shevchenko Kiev National University
  • М. С. Фрасинюк Taras Shevchenko Kiev National University
  • В. П. Хиля Taras Shevchenko Kiev National University

DOI:

https://doi.org/10.1007/2961

Keywords:

9, 10-dihydro-2H, 8H-chromeno[8, 7-e][1, 3]oxazin-2-one, coumarin, C- and O-aminomethylation, electrophilic substitution

Abstract

The reaction of the analogs of natural 3-arylbenzopyran-2-ones with electrophilic reagents of aminal structure was studied. Substituted 8-aminomethyl-3-aryl-7-hydroxycoumarins were synthesized. The optimum conditions were determined for the production of 9-alkyl- and 9-(het)arylmethyl derivatives of 3-aryl-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one in the series of analogs of natural 3‑arylbenzopyran-2-ones.

How to Cite
Bondarenko, S. P.; Frasinyuk, M. S.; Khilya, V. P. Chem. Heterocycl. Compd. 2010, 46, 529. [Khim. Geterotsikl. Soedin. 2010, 672.]

For this article in the English edition see DOI 10.1007/s10593-010-0541-y

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Published

2016-01-14

Issue

No. 5 (2010)

Section

Original Papers