MECHANOCHEMICAL AND SONOCHEMICAL HETEROCYCLIZATIONS

Authors

  • Emanuela Calcio Gaudino Dipartimento di Scienza e Tecnologia del Farmaco and NIS-Centre for Nanostructured Interfaces and Surfaces, University of Turin, Via P. Giuria 9, 10125 Turin
  • Silvia Tagliapietra Dipartimento di Scienza e Tecnologia del Farmaco and NIS-Centre for Nanostructured Interfaces and Surfaces, University of Turin, Via P. Giuria 9, 10125 Turin
  • Stefano Mantegna Dipartimento di Scienza e Tecnologia del Farmaco and NIS-Centre for Nanostructured Interfaces and Surfaces, University of Turin, Via P. Giuria 9, 10125 Turin
  • Giancarlo Cravotto Dipartimento di Scienza e Tecnologia del Farmaco and NIS-Centre for Nanostructured Interfaces and Surfaces, University of Turin, Via P. Giuria 9, 10125 Turin

DOI:

https://doi.org/10.1007/3418

Keywords:

heterocycles, ball mill, cyclization, green chemistry, ultrasound

Abstract

Heterocycle formation reactions require efficient catalysis and suitable physical activation. Sonochemistry and mechanochemistry can dramatically promote heterocyclizations in heterogeneous conditions using benign solvents and even in solventless conditions by means of ball mills. Besides facilitating quick cyclization, these technologies bring with them safer protocols, cost reduction, energy saving, process intensification, and waste minimization. The aim of this review is to describe a number of relevant synthetic advances in the lasttwo years and to highlight the huge unexploited potential of both sonochemistry and mechanochemistry.

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Published

2016-12-22

Issue

Vol. 52 No. 11 (2016): Non-classical methods of activation in chemistry of heterocyclic compounds

Section

Review Articles