3,4-DIHYDROQUINOXALIN-2-ONES: RECENT ADVANCES IN SYNTHESIS AND BIOACTIVITIES

Authors

  • Tone Kristoffersen Organic Chemistry Division, Department of Chemistry, UiT The Arctic University of Norway, N-9037 Tromsø
  • Jørn H. Hansen Organic Chemistry Division, Department of Chemistry, UiT The Arctic University of Norway, N-9037 Tromsø

DOI:

https://doi.org/10.1007/3633

Keywords:

quinoxalin-2-ones, antiviral agents, anti-inflammatory agents

Abstract

A summary of recent synthetic approaches to 3,4-dihydroquinoxalin-2-ones is discussed herein along with highlights of biological activity. The synthetic approaches include access to enantiopure 3,4-dihydroquinoxalin-2-ones from chiral pool amino acids via coupling/cyclization, Michael addition/cyclization cascades, 3,3-disubstituted systems from multicomponent couplings, Bargellini reaction, or photochemical reduction.

 

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Published

2017-03-16

Issue

Vol. 53 No. 3 (2017): Privileged heterocyclic scaffolds in chemical biology and drug discovery: synthesis and bioactivity

Section

Heterocycles in Focus