(5<i>S</i>,7<i>R</i>)-5-Aryl-7-methyl-4,5,6,7-tetrahydro[1,2,4]triazolo[1,5-<i>a</i>]pyrimidin-7-ols as products of three-component condensation

Authors

  • Sergey A. Komykhov STC "The Institute for Single Crystals", National Academy of Science of Ukraine, Kharkiv National V. N. Karazin University
  • Andrey A. Bondarenko STC "The Institute for Single Crystals", National Academy of Science of Ukraine
  • Vladimir I. Musatov STC "The Institute for Single Crystals", National Academy of Science of Ukraine
  • Mikhail V. Diachkov Zaporizhia State Medical University
  • Nikolay Yu. Gorobets STC "The Institute for Single Crystals", National Academy of Science of Ukraine
  • Sergey M. Desenko STC "The Institute for Single Crystals", National Academy of Science of Ukraine, Kharkiv National V. N. Karazin University

DOI:

https://doi.org/10.1007/3644

Keywords:

1H-1, 2, 4-triazol-3-amine, biological activity, microwave-assisted synthesis, molecular structure investigation, multicomponent reactions.

Abstract

(5S,7R)-5-Aryl-7-methyl-4,5,6,7-tetrahydro[1,2,4]triazolo[1,5-a]pyrimidin-7-ols were synthesized by three-component reactions of 1H-1,2,4-triazol-3-amine with aromatic aldehydes and acetone in the presence of TsOH. Antimicrobial and antifungal activities of these new substances were investigated in vitro.

 

Author Biographies

Sergey A. Komykhov, STC "The Institute for Single Crystals", National Academy of Science of Ukraine, Kharkiv National V. N. Karazin University

Senior researcher, Department of heterocyclic compounds

PhD

Andrey A. Bondarenko, STC "The Institute for Single Crystals", National Academy of Science of Ukraine

postgraduate student

Vladimir I. Musatov, STC "The Institute for Single Crystals", National Academy of Science of Ukraine

Senior researcher, Department of heterocyclic compounds

PhD

Mikhail V. Diachkov, Zaporizhia State Medical University

Assistant professor,

PhD

Nikolay Yu. Gorobets, STC "The Institute for Single Crystals", National Academy of Science of Ukraine

Senior researcher, Department of heterocyclic compounds

PhD

Sergey M. Desenko, STC "The Institute for Single Crystals", National Academy of Science of Ukraine, Kharkiv National V. N. Karazin University

Head of department of heterocyclic compounds,

D. Sci, Prof.

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Published

2017-04-04

Issue

Vol. 53 No. 3 (2017): Privileged heterocyclic scaffolds in chemical biology and drug discovery: synthesis and bioactivity

Section

Letters to the Editor