SYNTHESIS OF BIS-HETEROCYCLIC COMPOUNDS WITH A PHENYLENE BRIDGE FROM 1,4- AND 1,3-BIS(2-CHLORO-2-CYANOVINYL)BENZENES
DOI:
https://doi.org/10.1007/449Keywords:
1, 3-bis(2-chloro-2-cyanovinyl)benzene, 4-bis(2-chloro-2-cyanovinyl)benzene, pyrazole, pyrimidine, thiophene, catalytic olefinationAbstract
Reaction of binucleophiles with 1,4- and 1,3-bis(2-chloro-2-cyanovinyl)benzenes, synthesized using a catalytic olefination of terephthalic and isophthalic aldehydes, gave high yields of aminopyrazoles, 3-amino-5-arylthiophene-2-carboxylic acid esters, and 2,4-diamino-6-arylpyrimidines.
Authors: V. M. Muzalevskiy, A. M. Maharramov, N. G. Shikhaliev, S. Dzh. Geidarova, M. A. Mamedova, E. S. Balenkova, A. V. Shastin, and V. G. Nenajdenko.
English Translation in Chemistry of Heterocyclic Compounds, 2013, 49 (6), pp 909-914