SYNTHESIS AND ANTIMYCOBACTERIAL ACTIVITY OF PYRIDINIUM COMPOUNDS WITH SULFONYLACETAMIDE SUBSTITUENT IN <i>N</i>-ALKYL CHAIN

Authors

  • Марина М. Шулаева A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, 8 Akademika Arbuzova St., Kazan 420088
  • Марионелла А. Кравченко Ural Research Institute of Phthysiopulmonology – branch of the National Medical Research Center of Phthysiopulmonology and Infectious Diseases, Ministry of Health of the Russian Federation, 50 22-go Parts'yezda St., Yekaterinburg 620039
  • Вячеслав Э. Семенов A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, 8 Akademika Arbuzova St., Kazan 420088

DOI:

https://doi.org/10.1007/4590

Keywords:

carbamoylmethylsulfonyl group, pyridinium compounds, sulfonylacetamides, quaternization, antituberculosis activity

Abstract

Pyridines containing amine, amide, or hydrazide substituent were quaternized with (ω-haloalkyl)sulfonylacetamides, resulting in new pyridinium compounds that exhibited tuberculostatic activity against the strain H37Rv of Mycobacterium tuberculosis.

Authors: Marina M. Shulaeva*, Marionella A. Kravchenko, Vyacheslav E. Semenov

Author Biographies

Марина М. Шулаева, A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, 8 Akademika Arbuzova St., Kazan 420088

научный сотрудник лаборатории "Химия нуклеотидных оснований", к.х.н.

Марионелла А. Кравченко, Ural Research Institute of Phthysiopulmonology – branch of the National Medical Research Center of Phthysiopulmonology and Infectious Diseases, Ministry of Health of the Russian Federation, 50 22-go Parts'yezda St., Yekaterinburg 620039

Старший научный сотрудник лаборатории экспериментальных и диагностических методов исследования

Вячеслав Э. Семенов, A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, 8 Akademika Arbuzova St., Kazan 420088

заведующий лабораторией "Химия нуклеотидных оснований", д.х.н.

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Published

2018-10-17

Issue

Vol. 54 No. 9 (2018)

Section

Original Papers