<i>N</i>-DIFLUOROMETHYLATION OF MONOSUBSTITUTED POLYDENTATE AZOLES

Authors

  • Кирилл И. Петко Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094
  • Тарас М. Соколенко Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094
  • Андрей А. Филатов Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094
  • Виталий В. Половинко Enamine Ltd., 78 Chervonotkatska St., Kyiv 02
  • Эдуард Б. Русанов Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094
  • Вадим А. Дудко Enamine Ltd., 78 Chervonotkatska St., Kyiv 02
  • Юрий Л. Ягупольский Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094

DOI:

https://doi.org/10.1007/4948

Keywords:

imidazoles, pyrazoles, 1, 2, 4-triazoles, difluoromethylation, separation of isomers

Abstract

This study was focused on N-difluoromethylation of monosubstituted polydentate azoles (imidazoles, pyrazoles, and 1,2,4-triazoles) having two or three reactive sites. The substituent effects and role of reaction conditions in determining the product ratio was explored. In the majority of cases, the obtained mixtures of isomers were separated. The target products containing halogen substituents, amino or carboxy groups in the ring can serve as valuable starting compounds in the synthesis of practically useful products.

Authors: Kirill I. Petko*, Taras M. Sokolenko, Andrey A. Filatov, Vitaliy V. Polovinko, Eduard B. Rusanov, Vadim A. Dudko, Yurii L. Yagupolskii

Author Biography

Кирилл И. Петко, Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094

Кирилл ИгоревичПетко

отдел №8 старшинй научный сотрудник, кандидат химических наук.

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Published

2019-05-22

Issue

Vol. 55 No. 4/5 (2019): In memory of Professor Valerii Dmitrievich Orlov

Section

Original Papers