ALKYLATION OF 2-ACETYLAMINO-5-(BENZIMIDAZOL-2-YL)THIAZOLE DERIVATIVES

Authors

  • E. Б. Усова Kuban State Technological University
  • Е. Ю. Кaмбулов Kuban State Technological University
  • В. Е. Заводник Kuban State Technological University
  • Г. Д. Крапивин Kuban State Technological University

DOI:

https://doi.org/10.1007/540

Abstract

Alkylation of 2-acetylamino-5-(benzimidazol-2-yl)thiazole derivatives has been studied. In the system DMSO—KOH powder methylation of the amide-group nitrogen atom takes place mainly, while in the acetone-concentrated aqueous KOH system, the pyrrole nitrogen atom in the imidazole ring is preferentially methylated.

Authors: E. B. Usova, E. Yu. Kambulov, V. E. Zavodnik, and G. D. Krapivin.

English Translation in Chemistry of Heterocyclic Compounds, 1999, 35 (2), pp 231-239

http://link.springer.com/article/10.1007/BF02251716

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Published

2013-04-29

Issue

No. 2 (1999)

Section

Original Papers