SYNTHESIS OF 4-HETERYL-SUBSTITUTED DERIVATIVES OF METHYLPYRAZOLO[1,5-<i>a</i>]PYRAZINE-4-CARBOXYLATES
Authors
Назар М. Цизорик
Institute of Organic Chemistry, National Academy of Sciences of Ukraine,
5 Murmanska St., Kyiv 02094, Ukraine
Евгений В. Гринишин
Institute of Organic Chemistry, National Academy of Sciences of Ukraine,
5 Murmanska St., Kyiv 02094, Ukraine
National University ''Kyiv-Mohyla Academy'',
2 Hrygorija Skovorody St., Kyiv 04655, Ukraine
Анна Р. Мусийчук
Institute of Organic Chemistry, National Academy of Sciences of Ukraine,
5 Murmanska St., Kyiv 02094, Ukraine
Андрей В. Больбут
Institute of Organic Chemistry, National Academy of Sciences of Ukraine,
5 Murmanska St., Kyiv 02094, Ukraine
Enamine Ltd.,
78 Chervonotkatska St., Kyiv 02094, Ukraine
Methylpyrazolo[1,5-a]pyrazine-4-carboxylates were synthesized by palladium-catalyzed carbonylation of 4-chloropyrazolo[1,5-a]pyrazines at elevated pressure and converted via nitrile intermediates to the corresponding amidoximes and amidines. Cyclocondensation of the obtained amidoximes with trifluoroacetic anhydride or ethyl chloroformate and amidines with acetoacetate or ethyl ethoxymethylidenemalonate were used to synthesize new 4-(1,2,4-oxadiazolyl)- and 4-(pyrimidin-2-yl)-substituted pyrazolo[1,5-a]pyrazines.
Author Biography
Назар М. Цизорик, Institute of Organic Chemistry, National Academy of Sciences of Ukraine,
5 Murmanska St., Kyiv 02094, Ukraine
