SYNTHESIS AND CYTOTOXICITY OF PHENYLVINYL DERIVATIVES OF 4,6,6-TRIMETHYL-2-OXO-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBONITRILE

Authors

  • Э. Лукевиц Latvian Institute of Organic Synthesis, Riga LV-1006
  • Д. Янсоне Latvian Institute of Organic Synthesis, Riga LV-1006
  • Л. Лейте Latvian Institute of Organic Synthesis, Riga LV-1006
  • Ю. Попелис Latvian Institute of Organic Synthesis, Riga LV-1006
  • Г. Андреева Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Шестакова Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Домрачева Latvian Institute of Organic Synthesis, Riga LV-1006
  • В. Бридане Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Канепе Latvian Institute of Organic Synthesis, Riga LV-1006

DOI:

https://doi.org/10.1007/6562

Keywords:

4, 6, 6-trimethyl-2-oxo-1, 2, 5, 6-tetrahydropyridine-3-carbonitrile, styryl derivatives, condensation, toxicity, cytotoxicity

Abstract

A series of phenylvinyl derivatives of  4,6,6-trimethyl-2-oxo-1,2,5,6-tetrahydropyridine-3-carbonitriles has been synthesized and their cytotoxic activity towards HT-1080 (human fibrosarcoma) and MG 22A (mouse  hepatoma) tumor cells studied. It was found  that the 2-nitro-, 2- and 3-chloro, 2-fluoro, and 2-bromophenyl derivatives showed high cytotoxic activity towards both cell lines. The toxicity towards NIH 3T3 normal mouse embryonic fibroblasts depends on the nature and position of the substituent in the phenyl ring. The greatest selectivity of cytotoxic effect was seen in the 2-bromophenyl derivative.

How to Cite
Lukevics, E.; Jansone, D.; Leite, L.; Popelis, J.; Andreeva, G.;  Shestakova, I.; Domracheva, I.; Bridane,V.; Kanepe, I. Chem. Heterocycl. Compd. 2009, 45, 1226. [Khim. Geterotsikl. Soedin. 2009, 1529.]

For this article in the English edition see DOI 10.1007/s10593-010-0411-7

 

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Published

2022-02-10

Issue

No. 10 (2009)

Section

Original Papers