4-HYDROXY-2-QUINOLONES. 167. STUDY OF THE REACTION OF ETHYL 1-ALKYL-SUBSTITUTED 4-HYDROXY-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLATES WITH PHOSPHORUS OXYCHLORIDE

Authors

  • И. В. Украинец National University of Pharmacy, Kharkiv 61002
  • Н. Л. Березнякова National University of Pharmacy, Kharkiv 61002
  • А. А. Давиденко National University of Pharmacy, Kharkiv 61002
  • С. В. Слободзян Northern Michigan University, Marquette 49855, Michigan

DOI:

https://doi.org/10.1007/6610

Keywords:

ethyl 1-alkyl-4-chloro-2-oxo-1, 2-dihydroquinoline-3-carboxylates, phosphorus oxychloride, desalkylation

Abstract

Prolonged treatment of ethyl 1-alkyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylates with refluxing phosphorus oxychloride gives not only the target 4-chloro derivatives but is also accompanied by a marked loss of the 1-N-alkyl groups to form the side product 2,4-dichloro-3-ethoxycarbonylquinoline.

How to Cite
Ukrainets, I. V.; Bereznyakova, N. L.; Davidenko, A. A.; Slobodzian, S. V.
Chem. Heterocycl. Compd. 2009, 45, 952. [Khim. Geterotsikl. Soedin. 2009, 1198.]

For this article in the English edition see DOI 10.1007/s10593-009-0367-7

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Published

2022-02-16

Issue

No. 8 (2009)

Section

Original Papers