STUDIES OF 3-O-ACYL DERIVATIVES OF NALOXONE AS ITS POTENTIAL PRODRUGS

Authors

  • И. В. Украинец National University of Pharmacy, Kharkiv 61002
  • А. А. Ткач National University of Pharmacy, Kharkiv 61002
  • О. В. Горохова National University of Pharmacy, Kharkiv 61002
  • А. В. Туров Taras Shevchenko National University, Kiev 01033
  • И. В. Линский Institute for Neurology, Psychiatry, and Narcology, Academy of Medical Sciences of Ukraine, Kharkiv 61068

DOI:

https://doi.org/10.1007/6741

Keywords:

3-hydroxymorphinans, opiate receptor antagonists, naloxone, prodrugs, acylation, X-ray structural analysis

Abstract

An efficient method has been proposed for the preparation of a series of 3-O-acyl derivatives of naloxone. The features of the steric structure and NMR spectra are discussed. Pharmaceutical investigation has shown the promise within the synthesized compounds of creating opiate receptor antagonist compounds with prolonged action.

How to Cite
Ukrainets, I. V.; Tkach, A. A.; Gorokhova, O. V.; Turov, A. V.; Linsky, I. V.  Chem. Heterocycl. Compd. 2009, 45, 405. [Khim. Geterotsikl. Soedin. 2009, 519.]

For this article in the English edition see DOI 10.1007/s10593-009-0278-7


Downloads

Published

2022-04-22

Issue

No. 4 (2009)

Section

Original Papers