HETEROCYCLIC ANALOGS OF COMBRETASTATIN A-4

Authors

  • С. Ф. Василевский Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090
  • М. П. Давыдова Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090
  • Г. А. Толстиков N. N. Vorozhtsov Institute for Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090

DOI:

https://doi.org/10.1007/7217

Keywords:

acetylenes, combretastatin A-4, heterocyclization, homogeneous catalysis, cross-coupling

Abstract

A novel route is proposed for the synthesis of  heterocyclic analogs of the naturally occurring combretastatin A-4 based on the reaction  of α-acetylenic ketones with polyfunctional nucleophiles (hydroxylamine, hydrazine, guanidine). Previously unknown combretastatin A-4 analogs with azole and azine bridges were obtained.

How to Cite
Vasilevsky, S. F.; Davydova, M. P.; Tolstikov, G. A.  Chem. Heterocycl. Compd. 2008, 44, 1257. [Khim. Geterotsikl. Soedin. 2008, 1545.]

For this article in the English edition see DOI 10.1007/s10593-009-0171-4


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Published

2022-11-25

Issue

No. 10 (2008)

Section

Original Papers