FEATURES OF THE REACTION OF UNSYMMETRICAL 2-MERCAPTOIMIDAZOLES WITH AROMATIC AND ALIPHATIC KETONES

Authors

  • С. Г. Джавахишвили State Science Foundation, Science Technology Complex, Institute of Monocrystals, Ukraine National Academy of Sciences, Kharkiv 61001
  • А. В. Борисов National Pharmaceutical University, Kharkiv 61002
  • В. М. Никитченко V. N. Karazin National University, Kharkiv 61077
  • С. Н. Коваленко National Pharmaceutical University, Kharkiv 61002

DOI:

https://doi.org/10.1007/7708

Keywords:

6-R4-3-R2-2-R3-benzo[4, 5]imidazo[2, 1-b][1, 3]thiazole 7-R4-3-R2-2-R3-benzo[4, 3]thiazole, 3-R3 -2-R2 -6-R1 -imidazo[2, 3]thiazoles, 6-R1 -1H-2-mercaptobenzo[d]imidazoles, 4-R1-1H-2-mercaptoimidazole, X-ray analysis, selectivity

Abstract

The cyclization of unsymmetrical 2-mercaptoimidazoles with aliphatic and aromatic ketones has been studied. Using 1H NMR and X-ray analysis it has been shown that 4-R1-1H-2-mercaptoimidazoles undergo selective oxidative cyclization to the corresponding 3-R3-2-R2-6-R1-imidazo[2,1-b][1,3]thiazoles while 6-R4-1H-2-mercaptobenzo[d]imidazoles give a mixture of 6-R4-3-R2-2-R3-benzo[4,5]imidazo[2,1-b][1,3]thiazole and 7-R4-3-R2-2-R3-benzo[4,5]imidazo[2,1-b][1,3]thiazole in the ratio 1 : 1.

How to Cite
Dzhavakhishvili, S. G.; Borisov, A. V.; Nikitchenko, V. M.; Kovalenko, S. N.  Chem. Heterocycl. Compd. 2007, 43, 98. [Khim. Geterotsikl. Soedin. 2007, 115.]

For this article in the English edition see DOI 10.1007/s10593-007-0015-z


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Published

2023-04-06

Issue

No. 1 (2007)

Section

Original Papers