SYNTHESIS OF PYRROLO[1,2-<i>a</i>][1,6]BENZODIAZONINES FROM PYRROLO[1,2-<i>a</i>][1,4]BENZODIAZEPINES AND ALKYNES CONTAINING ELECTRON-ACCEPTOR SUBSTITUENTS

Authors

  • Л. Г. Воскресенский Peoples' Friendship University of Russia
  • Т. Н. Борисова Peoples' Friendship University of Russia
  • М. И. Бабаханова Peoples' Friendship University of Russia
  • Т. М. Червякова Peoples' Friendship University of Russia
  • А. А. Титов Peoples' Friendship University of Russia
  • А. В. Бутин Research Institute for Heterocyclic Compounds, Kuban State University of Technology; Perm State National Research University
  • Т. А. Неволина Research Institute for Heterocyclic Compounds, Kuban State University of Technology; Perm State National Research University
  • В. Н. Хрусталев A. N. Nesmeyanov Institute of Organoelemental Compounds, Russian Academy of Sciences
  • А. В. Варламов Peoples' Friendship University of Russia

DOI:

https://doi.org/10.1007/786

Keywords:

pyrrolo[1, 2-a][1, 4]benzodiazepines, 6]benzodiazonines, activated alkynes, diazepine ring expansion, diazepine ring opening

Abstract

It has been established that the reaction of pyrrolo[1,2-a][1,4]benzodiazepines with activated alkynes gives pyrrolo[1,2-a][1,6]benzodiazonines as the products of diazepine ring expansion. In the case of pyrrolo[1,2-a][1,4]benzodiazepine, substituted with formyl group at the pyrrole ring, both expansion and cleavage of the diazepine fragment can occur.

Authors: L. G. Voskressensky, T. N. Borisova, M. I. Babakhanov, T. M. Chervyakova, A. A. Titov, A. V. Butin, T. A. Nevolina, V. N. Khrustalev, and A. V. Varlamov.

English Translation in Chemistry of Heterocyclic Compounds, 2013, 49 (7), pp 1024-1032

http://link.springer.com/article/10.1007/s10593-013-1340-z

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Published

2013-07-02

Issue

No. 7 (2013)

Section

Original Papers