SYNTHESIS AND SOME TRANSFORMATIONS OF γ-(<i>p</i>-FLUOROPHENYL)-γ-(2-FURYL)PROPYLAMINE

Authors

  • Н. С. Арутюнян A. L. Mndzhoyan Institute of Fine Organic Chemistry, National Academy of Sciences of the Republic of Armenia, Erevan 375014
  • Л. А. Акопян A. L. Mndzhoyan Institute of Fine Organic Chemistry, National Academy of Sciences of the Republic of Armenia, Erevan 375014
  • Г. М. Снхчян A. L. Mndzhoyan Institute of Fine Organic Chemistry, National Academy of Sciences of the Republic of Armenia, Erevan 375014
  • О. А. Папоян A. L. Mndzhoyan Institute of Fine Organic Chemistry, National Academy of Sciences of the Republic of Armenia, Erevan 375014
  • Г. А. Паносян Molecule Structure Research Center, National Academy of Sciences of the Republic of Armenia, Erevan 375014
  • Г. А. Геворгян A. L. Mndzhoyan Institute of Fine Organic Chemistry, National Academy of Sciences of the Republic of Armenia, Erevan 375014

DOI:

https://doi.org/10.1007/7997

Keywords:

γ-(p-fluorophenyl)-γ-(2-furyl)propylamine, ethyl furfurylidenecyanoacetate, ethyl β-(p-fluorophenyl)-β-(2-furyl)propionate, reduction, deethoxycarbonylation

Abstract

Ethyl  α-cyano-β-(p-fluorophenyl)-β-(2-furyl)propionate was obtained by the condensation of ethyl α-cyano-β-(2-furyl)acrylate with p-fluorophenylmagnesium bromide. Its deethoxycarbonylation led to β-(p-fluorophenyl)-β-(2-furyl)propionitrile. Reduction of the nitrile with lithium aluminum hydride gave γ-(p-fluorophenyl)-γ-(2-furyl)propylamine. Some transformations of the latter were studied.

How to Cite
Arutyunyan, N. S.; Akopyan, L. A.; Snkhchyan, G. M.; Papoyan, O. A.; Panosyan, G. A.; Gevorgyan, G. A.  Chem. Heterocycl. Compd. 2006, 42, 440. [Khim. Geterotsikl. Soedin. 2006, 503.]

For this article in the English edition, see DOI 10.1007/s10593-006-0108-0


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Published

2023-08-25

Issue

No. 4 (2006)

Section

Original Papers