REACTION OF 3-NITRO-1,2,4-TRIAZOLE DERIVATIVES WITH ALKYLATING AGENTS. 1. ALKYLATION IN THE PRESENCE OF ALKALI

Authors

  • Г. Т. Суханов Institute of Problems of Chemical Energy Technology, Siberian Branch of the Russian Academy of Sciences, Biisk 659322
  • А. Ю. Лукин Federal State Unitary Enterprise, Altai Federal Industrial Science Center, Biisk 659322

DOI:

https://doi.org/10.1007/8243

Keywords:

1-alkyl-3-nitro-1, 2, 4-triazoles, 1-alkyl-5-nitro-1, 3-nitro-1, alkylation, regioselectivity

Abstract

Alkylation of 3-nitro-1,2,4-triazole and 5-methyl-3-nitro-1,2,4-triazole with dialkyl sulfates or alkyl halides in the presence of alkali proceeds with a low selectivity for the alkylating agent with the formation of two regioisomers at the N(1) and N(2) atoms of the heterocycle. Depending on the reaction conditions the proportion of the N(2) isomer was 14.6-33.8%.

How to Cite
Sukhanov, G. T.; Lukin, A. Yu.  Chem. Heterocycl. Compd. 2005, 41, 861. [Khim. Geterotsikl. Soedin. 2005, 1020.]

For this article in the English edition, see DOI 10.1007/s10593-005-0239-8


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Published

2023-10-31

Issue

No. 7 (2005)

Section

Original Papers