THE SYNTHESIS OF FURAZANO- AND THIADIAZOLOPYRAZINE STEROIDS AND THEIR ANTIPROLIFERATIVE ACTIVITY

Authors

  • Светлана К. Воронцова N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia
  • Александр М. Щербаков Department of Experimental Tumor Biology, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, 24, Build. 15 Kashirskoe highway, Moscow 115522, Russia; Gause Institute of New Antibiotics, 11, Build. 1 B. Pirogovskaya St., Moscow 119021, Russia
  • Михаил Е. Миняев N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia
  • Леонид Менчиков N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia
  • Игорь В. Заварзин N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia

Keywords:

17β-acetoxy-3-methoxyestra-1,3,5(10)-triene, [1,2,5]oxadiazolo[3,4-b]pyrazine, steroid, [1,2,5]thiadiazolo[3,4-b]pyrazine, antibacterial and anti-breast cancer

Abstract

An effective method for the synthesis of heterocyclic steroids with the [1,2,5]oxadiazolo[3,4-b]pyrazine and [1,2,5]thiadiazolo[3,4-b]pyrazine fragments was developed. The structure of the products was confirmed by X-ray structural analysis. The resulting compounds showed high antiproliferative activity against breast (MCF7) and prostate (22Rv1) cancer cells, which was not inferior to that of cisplatin and abiraterone acetate.

 

Author Biography

Леонид Менчиков, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia

Кандидат химических наук, научный сотрудник

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Published

2024-05-28

Issue

Vol. 60 No. 3/4 (2024)

Section

Short Communications