TRIFLUOROMETHYL-SUBSTITUTED DI- AND TETRAHYDROAZOLOPYRIMIDINES

Abstract

The condensation of 4,4,4-trifluoro-1-phenylbut-1-en-3-one with 2-aminobenzimidazole, 3-amino-1,2,4-triazole, and 5-aminotetrazole gives hydroxy-substituted tetrahydro derivatives of pyrimido[1,2-a]-benzimidazole, and of 1,2,4-triazolo-, and tetrazolo[1,5-a]pyrimidine. Dehydration of them to the corresponding dihydroazolopyrimidines has been carried out. An X-ray structural investigation was carried out and the molecular structure of 5-hydroxy-7-phenyl-5-trifluoromethyl-4,5,5,7-tetrahydrotetrazolo[1,5-a]pyrimidine is discussed.

How to Cite
Desenko, S. M.; Gladkov, E. S.; Nenaidenko, V. G.; Shishkin, O. V.; Shishkina, S. V. Chem. Heterocycl. Compd. 2004, 40, 65. [Khim. Geterotsikl. Soedin. 2004, 71.]

For this article in the English edition, see DOI 10.1023/B:COHC.0000023769.66759.7d