NEW HETEROCYCLIC SYSTEMS BASED ON 5,6,7,8-TETRAHYDROISOQUINOLINES

Authors

  • С. Н. Сираканян A. L. Mndzhoyan Institute of Fine Organic Chemistry, the Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
  • В. Г. Карцев InterBioScreen Ltd.
  • А. А. Овакимян A. L. Mndzhoyan Institute of Fine Organic Chemistry, the Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
  • А. С. Норавян A. L. Mndzhoyan Institute of Fine Organic Chemistry, the Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
  • А. А. Шахатуни A. L. Mndzhoyan Institute of Fine Organic Chemistry, the Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia

DOI:

https://doi.org/10.1007/888

Keywords:

furo[3, 2-d]pyrimidines, 5, 6, 7, 8-tetrahydroisoquinoline, amination, chlorination, condensation, cyclization, Dimroth rearrangement

Abstract

A method has been developed for the synthesis of new 8-amino-substituted 5-propyl(isobutyl)-1,2,3,4-tetrahydropyrimido[4',5':4,5]furo[2,3-c]isoquinolines from 3-oxo derivatives of 5,6,7,8-tetrahydroisoquinolines. Isomeric triazoles, condensed at the edge [c] of the pyrimidine ring, have been obtained from the 8-hydrazino derivatives. A Dimroth rearrangement was carried out in acidic medium.

Authors: S. N. Sirakanyan, V. G. Kartsev, A. A. Hovakimyan, A. S. Noravyan, and A. A. Shakhatuni

English Translation in Chemistry of Heterocyclic Compounds, 2012, 48 (11), pp 1676-1683

http://link.springer.com/article/10.1007/s10593-013-1192-6

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Published

2013-08-27

Issue

No. 11 (2012)

Section

Original Papers