SYNTHESIS OF HEXA- AND OCTAHYDROPYRIDO[3'2':4,5]THIENO[3,2-<i.d</i>]PYRIMIDINES

Authors

  • В. В. Доценко East-Ukrainian National University, Lugansk 91034
  • С. Г. Кривоколыско East-Ukrainian National University, Lugansk 91034
  • В. П. Литвинов N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991

Keywords:

tetrahydropyridinethiolate, thienopyridine, partially hydrogenated pyridothienopyrimidines, cyclization

Abstract

The reaction of N-methylmorpholinium 4-(2-chlorophenyl)-5-cyano-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolate with chloroacetamide in DMF in the presence of an excess of KOH gave 3-amino-2-carbamoyl-4-(2-chlorophenyl)-6-oxo-4,5,6,7-tetrahydrothieno[2,3-b]pyridine. Refluxing the latter with acyl chlorides in AcOH or heating in formic acid gave hexahydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine derivatives and reaction with cyclohexanone gave a spiro-linked octahydropyrido[3',2':4,5]thieno-[3,2-d]pyrimidine.

How to Cite
Dotsenko, V. V.; Krivokolysko, S. G.; Litvinov, V. P. Chem. Heterocycl. Compd. 2003, 39, 110. [Khim. Geterotsikl. Soedin. 2003, 117.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1023033027915

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Published

2003-01-25

Issue

No. 1 (2003)

Section

Original Papers