POLYFUNCTIONAL PYRAZOLES. 7. ETHYL 1-ARYL-4-FORMYLPYRAZOLE-3-CARBOXYLATES IN THE SYNTHESIS OF 2-ARYL-2,4-DIHYDRO-6<i>H</i>-THIENO[3,4-<i>c</i>]PYRAZOL-6-ONES

Authors

  • М. К. Братенко Bukovinian State Medical University
  • М. М. Барус Bukovinian State Medical University
  • М. В. Вовк Institute of Organic Chemistry, National Academy of Sciences of Ukraine

DOI:

https://doi.org/10.1007/915

Keywords:

2, 4-dihydro-6H-thieno[3, 4-c]pyrazol-6-ones, ethyl 4-formylpyrazole-3-carboxylates, 4-sulfanylmethylpyrazole-3-carboxylic acids, cyclization

Abstract

A convenient method has been developed for the synthesis of 2,4-dihydro-6H-thieno[3,4-c]pyrazol-6‑ones by means of an intramolecular cyclization of 4-sulfanylmethylpyrazole-3-carboxylic acids. The latter were prepared from ethyl 4-formylpyrazole-3-carboxylates via the intermediate 4-hydroxy-methyl-, 4-chloromethyl-, and 4-thioureidomethyl derivatives.

Authors: M. K. Bratenko, M. M. Barus, and M. V. Vovk

English Translation in Chemistry of Heterocyclic Compounds, 2013, 48 (10), pp 1545-1549

http://link.springer.com/article/10.1007/s10593-013-1171-y

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Published

2013-08-29

Issue

No. 10 (2012)

Section

Original Papers