SYNTHESIS OF CEРHALOSРORINS CARRYING ISOXAZOLYL ACETAMDO AND RELATED SIDЕ CHAINS

Authors

  • Ferenc Sztaricskai Research Group for Antibiotics of the Hungarian Academy of Sciences, H- 4010 Debrecen, P. O. Box 70
  • Gyula Batta Research Group for Antibiotics of the Hungarian Academy of Sciences, H- 4010 Debrecen, P. O. Box 70
  • Zoltán Dinya Research Group for Antibiotics of the Hungarian Academy of Sciences, H- 4010 Debrecen, P. O. Box 70
  • István F. Pelyvás Research Group for Antibiotics of the Hungarian Academy of Sciences, H- 4010 Debrecen, P. O. Box 70
  • Pál Herczegh Research Group for Antibiotics of the Hungarian Academy of Sciences, H- 4010 Debrecen, P. O. Box 70
  • Таmás E. Gunda Research Group for Antibiotics of the Hungarian Academy of Sciences, H- 4010 Debrecen, P. O. Box 70
  • István Koczka Research Group for Antibiotics of the Hungarian Academy of Sciences, H- 4010 Debrecen, P. O. Box 70

Abstract

Starting from 3,5-dimеthylisoxazolе the carboxylic acids I and V, the amino acids VIII (L-) and IX D-), and the ureido acids X (L-) and XI (D-) were prepared, which were used for the synthesis of the new cephalosporins XVIIb, XXa—c (L-) and XXIb (D-) . The in vitro antibacterial activity of these semi-synthetic antibiotics was studied. The resorption of XVIIb was investigated in mice.

How to Cite
Sztaricskai, F.; Batta, G.; Dinya, Z.; Pelyvás, I. F.; Herczegh, P.; Gunda, Т. E.; Koczka, I. Chem. Heterocycl. Compd. 1998, 34, 1296. [Khim. Geterotsikl. Soedin. 1998, 1524.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02256810

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Published

1998-11-25

Issue

No. 11 (1998)

Section

Original Papers