7α-MЕTНОХY-2-[(SUBSTITUTЕD)MЕTHYLЕNЕ]CЕPHЕM SULFONЕS AS INHIBITORS OF HUMAN LEUKOCYTE ELASTASE AND THROMBIN

Авторы

  • Andhe V. Narender Reddy SynPhar Laboratories Inc., #2, 4290-91А Street, Edmonton, Alberta T6E 5V2
  • Charles Y. Fiakpui SynPhar Laboratories Inc., #2, 4290-91А Street, Edmonton, Alberta T6E 5V2
  • David P. Czajkowski SynPhar Laboratories Inc., #2, 4290-91А Street, Edmonton, Alberta T6E 5V2
  • Jadwiga Kaleta SynPhar Laboratories Inc., #2, 4290-91А Street, Edmonton, Alberta T6E 5V2
  • Ronald G. Micetich SynPhar Laboratories Inc., #2, 4290-91А Street, Edmonton, Alberta T6E 5V2
  • Samarendra N. Maiti SynPhar Laboratories Inc., #2, 4290-91А Street, Edmonton, Alberta T6E 5V2

Аннотация

A series of 7α-mеthоху-2-[(substituted) methylene]cephem sulfones was synthesized. The compounds with an acetoxy group at G-З' position as a leaving group were found to be potent inhibitors of ALE. Selected compounds are also found to be aniithrombin agents.

How to Cite
Reddy, A. V. N.; Fiakpui, C. Y.; Czajkowski, D. P.; Kaleta, J.; Micetich, R. G.; Maiti, S. N. Chem. Heterocycl. Compd. 1998, 34, 1282. [Khim. Geterotsikl. Soedin. 1998, 34, 1510.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02256808

Загрузки

Опубликован

1998-11-25

Выпуск

№ 11 (1998)

Раздел

Оригинальные статьи