SYNTHESIS OF NEW SPIROOXINDOLOPYRROLIDINES VIA THREE-COMPONENT REACTION OF ISATINS, α-AMINO ACIDS, AND (<i>E</i>)-3-ARYL-2-CYANOACRYLAMIDES OR (<i>E</i>)-3-ARYL-2-(4-ARYLTHIAZOL-2-YL)ACRYLONITRILES

Авторы

  • Tetyana L. Pavlovska ГНУ "НТК "Институт монокристаллов" НАН Украины
  • Victoria V. Lipson V. Ya. Danilevsky Institute of Endocrine Pathology Problems, Academy of Medical Sciences of Ukraine, 10 Alchevskih St., Kharkiv 61002
  • Svetlana V. Shishkina State Scientific Institution “Institute for Single Crystals” of National Academy of Sciences of Ukraine, 60 Nauky Ave., Kharkiv 61002
  • Vladimir I. Musatov State Scientific Institution “Institute for Single Crystals” of National Academy of Sciences of Ukraine, 60 Nauky Ave., Kharkiv 61002
  • Julia A. Nichaenko V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv 61077
  • Victor V. Dotsenko Kuban State University, 149 Stavropolskaya St., Krasnodar 350040

DOI:

https://doi.org/10.1007/3602

Ключевые слова:

azomethine ylide, cyanoacrylamide, sarcosine, spiro[indoline-3, 2'-pyrrolidin]-2-one, thiazoleacrylonitrile

Аннотация

A series of novel spirooxindolopyrrolidine derivatives has been prepared via a three-component 1,3-dipolar cycloaddition reaction of 2-oxindoleazomethine ylides generated in situ from isatin and sarcosine or valine with (E)-3-aryl-2-cyanoacrylamides or (E)-3-aryl-2-(4-arylthiazol-2-yl)acrylonitriles as dipolarophiles. To rationalize the observed regio- and stereoselectivity, calculations of the geometrical structures of all possible conformers and charge distribution in the reacting systems were performed.

Биография автора

Tetyana L. Pavlovska, ГНУ "НТК "Институт монокристаллов" НАН Украины

аспирант

Загрузки

Опубликован

2017-05-02

Выпуск

Том 53 № 4 (2017): Многокомпонентные реакции в синтезе гетероциклов

Раздел

Оригинальные статьи