FACILE ONE-POT SYNTHESIS OF PYRAZOLO[1,5-<i>a</i>]PYRAZINE SCAFFOLD

Авторы

  • O. V. Zaremba National University of Pharmacy
  • N. Yu. Gorobets Department of Chemistry of Heterocyclic Compounds, SSI "Institute for Single Crystals", National Academy of Science of Ukraine
  • S. S. Kovalenko National University of Pharmacy
  • O. G. Drushlyak National University of Pharmacy
  • O. Yu. Grevtsov National University of Pharmacy
  • S. M. Kovalenko National University of Pharmacy

DOI:

https://doi.org/10.1007/366

Ключевые слова:

azolocarboxamidoacetals, 6, 7-dihydropyrazolo[1, 5-a]pyrazin-4(5H)-one, 2, 2-dimethoxyethanamine, pyrazole-3-carboxilic acid, pyrazolo[1, one-pot reaction

Аннотация

A series of novel pyrazolo[1,5-a]pyrazine derivatives has been synthesized using facile one-pot three-step protocol starting from pyrazole-3-carboxilic acids. The process occurs via amide formation with consequent pyrazine ring closure, hydrolysis, and dehydration. 7-Hydroxy-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one and 7-methoxy-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one have been isolated as intermediate compounds.

Also published in Chemistry of Heterocyclic Compounds, 2013, 49 (6), pp 915-921

http://link.springer.com/article/10.1007/s10593-013-1326-x

Биографии авторов

O. V. Zaremba, National University of Pharmacy

Oleg Viktorovich Zaremba

N. Yu. Gorobets, Department of Chemistry of Heterocyclic Compounds, SSI "Institute for Single Crystals", National Academy of Science of Ukraine

Nikolay Yuriyovich Gorobets

S. S. Kovalenko, National University of Pharmacy

Svitlana Sergiyivna Kovalenko

O. G. Drushlyak, National University of Pharmacy

Oleksandr Grigorievich Drushlyak

O. Yu. Grevtsov, National University of Pharmacy

Oleksandr Yuriyovich Grevtsov

S. M. Kovalenko, National University of Pharmacy

Sergiy Mikolayovich Kovalenko

Загрузки

Опубликован

2013-06-13

Выпуск

№ 6 (2013)

Раздел

Оригинальные статьи