Design, synthesis, and biological evaluation of new 1-aryl-4-(β-D-fructopyranos-3-<i>O</i>-yl)methyl-1<i>H</i>-1,2,3-triazole derivatives

Авторы

  • Vennam Dinesh Kumar Reddy Gitam Deemed to be University
  • Thatipamula Ranjith Kumar Gitam Deemed to be University
  • Haridasyam Sharath Babu Gitam Deemed to be University
  • Koppula Shiva kumar Gitam Deemed to be University

DOI:

https://doi.org/10.1007/4379

Ключевые слова:

arylazide, 1-aryl-4-(β-D-fructopyranos-3-O-yl)methyl-1H-1, 2, 3-triazoles, 3-O-propargyl-β-D-fructopyranose, antibacterial activity, antifungal activity, click chemistry, molecular docking simulation.

Аннотация

New 1-aryl-4-(β-D-fructopyranos-3-O-yl)methyl-1H-1,2,3-triazole derivatives have been synthesized by a CuAAC reaction and their antibacterial and antifungal activity has been evaluated. Some of the derivatives showed remarkable in vitro antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Klebsiella pneumoniae and moderate antifungal activity. In addition, molecular docking studies of these compounds into the active site of Staphylococcus aureus tyrosyl-tRNA synthetase were performed. The docking study revealed that all compounds have considerable binding energies and good affinity toward the active site of the enzyme.

Биографии авторов

Vennam Dinesh Kumar Reddy, Gitam Deemed to be University

Department of Chemistry

Thatipamula Ranjith Kumar, Gitam Deemed to be University

Department of Chemistry

Haridasyam Sharath Babu, Gitam Deemed to be University

Department of Chemistry

Koppula Shiva kumar, Gitam Deemed to be University

Department of Chemistry

Загрузки

Опубликован

2018-07-25

Выпуск

Том 54 № 6 (2018)

Раздел

Оригинальные статьи