MICROWAVE-ASSISTED CU-CATALYZED C–C BOND FORMATION: ONE-POT SYNTHESIS OF FULLY SUBSTITUTED 1,2,3-TRIAZOLES USING NONSYMMETRICAL IODOALKYNES AND THEIR BIOLOGICAL EVALUATION

Авторы

  • Nagavelli Vasudeva Reddy
  • Sirassu Narsimha
  • Kumaraswamy Battula
  • Yellu Narsimha Reddy

DOI:

https://doi.org/10.1007/4644

Ключевые слова:

fused 1, 2, 3-triazole, ionic liquids, anticancer activity, microwave irradiation.

Аннотация

A copper-catalyzed one-pot synthesis of fused benzothiazino[1,2,3]triazolo[4,5-c]quinolinone derivatives from 1-iodoalkynes with different aryl azides via an in situ generated 5-iodotriazole intermediate in [BMIM]PF6 under microwave irradiation is reported. The reaction provided the desired fused 1,2,3-triazoles in good to excellent yields. Anticancer activity of the synthesized compounds has been screened in vitro against different cancer cell lines (MCF-7, HeLa, A-549, and IMR-32). Some of the derivatives showed remarkable anticancer activity against two cancer cell lines – MCF-7 and A-549. The remaining compounds have shown good to moderate activity against tested cell lines.

Опубликован

2019-01-09

Выпуск

Раздел

Оригинальные статьи