ENVIRONMENTALLY BENIGN ONE-POT MULTICOMPONENT SYNTHESIS OF 1,4-DIHYDROPYRIDINE DERIVATIVES APPLYING MONTMORILLONITE K10 AS REUSABLE CATALYST

Авторы

  • Vemulapati Hanuman Reddy
  • Avula Krishna Kumari
  • Guda Mallikarjuna Reddy
  • Yellala Venkata Rami Reddy
  • Grigory V. Zyryanov
  • Jarem Raul Garcia Department of Chemistry, State University of Ponta Grossa,General Carlos Cavalcanti Ave., 4748 – CEP 84030-900, Ponta Grossa, Paraná, Brazil
  • Nemallapudi Bakthavatchala Reddy
  • Aluru Rammohan

DOI:

https://doi.org/10.1007/4704

Ключевые слова:

1, 4-dihydropyridine, montmorillonite K10, water–ethanol, atom economy, environmentally benign synthesis, one-pot synthesis

Аннотация

Environmentally benign one-pot multicomponent synthesis of different 1,4-dihydropyridine derivatives using montmorillonite K10 has been achieved. The montmorillonite K10-catalyzed reaction of aromatic aldehyde, malononitrile, substituted aniline, and diethyl acetylenedicarboxylate in H2O–EtOH allows to obtain structurally diverse 1,4-dihydropyridines in high yields. Possibility to recover and
reuse the acidic catalyst in up to five catalytic cycles has been  demonstrated. Short reaction times, suppressed formation of side products, inexpensive and nontoxic solvent system, catalyst recovery, and simple workup procedure are the main advantages of the developed synthetic method.

Опубликован

2019-02-13

Выпуск

Раздел

Оригинальные статьи