RECENT ADVANCES IN THE C(1)-FUNCTIONALIZATION OF TETRAHYDROISOQUINOLINES <i>via</i> MULTICOMPONENT REACTIONS

Авторы

  • Pavneet Kaur Laboratory of Organic Chemistry, Department of Chemistry, Central University of Punjab, Bathinda 151001
  • Rakesh Kumar Laboratory of Organic Chemistry, Department of Chemistry, Central University of Punjab, Bathinda 151001

DOI:

https://doi.org/10.1007/5475

Ключевые слова:

heterocyclic compounds, iminium ion, tetrahydroisoquinoline, C(1)-functionalization, multicomponent reactions

Аннотация

1,2,3,4-Tetrahydroisoquinoline is an important structural motif of various natural products and therapeutic lead compounds. In recent years, considerable research interest has been witnessed toward synthesis of its C(1)-substituted derivatives, since they can act as precursors for various alkaloids displaying multifarious biological activities. This minireview offers short and non-exhaustive epitome of various multicomponent reactions for the C(1)-functionalization of 1,2,3,4-tetrahydroisoquinolines. In particular, reactions involving isomerization of iminium intermediate (exo/endo isomerization) are highlighted for the period of 2013–2019.

Биография автора

Rakesh Kumar, Laboratory of Organic Chemistry, Department of Chemistry, Central University of Punjab, Bathinda 151001

Assistant Professor

Department of Chemical Sciences, School of Basic and Applied Sciences,

Загрузки

Опубликован

2020-04-30

Выпуск

Том 56 № 4 (2020): Зеленая химия гетероциклов

Раздел

Обзорные статьи