SYNTHETIC STUDIES TOWARD NOVEL PYRROLOBENZODIAZEPINE–COUMARIN HYBRIDS

Авторы

  • Guna Sakaine Latvijas Organiskās sintēzes institūts
  • Gints Smits Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006, Latvia
  • Pavel Arsenyan Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006, Latvia

DOI:

https://doi.org/10.1007/5567

Ключевые слова:

coumarin, pyrrolobenzodiazepines, pyrrolobenzodiazepine–coumarin hybrids, anticancer agents.

Аннотация

A comprehensive screening of known methods for the synthesis of coumarins was performed in order to obtain a new type of pyrrolobenzodiazepine–coumarin hybrids. A Pechmann condensation turned out to be the method of choice for successful synthesis of the desired hybrid starting from the corresponding phenol derivative and malic acid. Overall, the desired pyrrolobenzodiazepine–coumarin hybrid was obtained in a 3 step sequence starting from readily available starting materials – L-proline methyl ester and
4-methoxyanthranilic acid.

Загрузки

Опубликован

2020-05-28

Выпуск

Том 56 № 5 (2020)

Раздел

Оригинальные статьи