SYNTHESIS, REACTIONS AND BIOLOGICAL ACTIVITY OF 2-SUBSTITUTED 3-CYANO-4,6-DIMETHYLPYRIDINE DERIVATIVES

Авторы

  • F. A. Yassin Chemistry Department, Faculty of Science, Zagazig University, Zagazig

DOI:

https://doi.org/10.1007/6876

Ключевые слова:

isoxazolopyridine, pyrazolopyridine, pyridine-3-carbonitrile, pyridoquinazoline, antibacterial activity

Аннотация

The reaction of 2-chloro-4,6-dimethylpyridine-3-carbonitrile with  hydrazine hydrate, hydroxylamine, and anthranilic acid afforded the corresponding pyrazolo, isoxazolo, and pyridoquinazoline derivatives. Alkylation of 2-mercapto-4,6-dimethyl-
pyridine-3-carbonitrile with ethyl chloroacetate or phenacyl bromide followed by cyclization in NaOH gave thienopyridine derivatives. Diazotization of ethyl 3-amino-4,6-dimethylthiеno[2,3-b]pyridine-2-carboxylate followed by the reaction with thiourea, guanidine carbonate, and hydroxylamine hydrochloride gave the corresponding thienopyridine derivatives. The biological activity of some new compounds has been discussed.

How to Cite
Yassin, F. A.  Chem. Heterocycl. Compd. 2009, 45, 35. [Khim. Geterotsikl. Soedin. 2009, 43.]

For this article in the English edition see DOI https://doi.org/10.1007/s10593-009-0222-x

Опубликован

2022-07-06

Выпуск

Раздел

Оригинальные статьи