SYNTHESIS OF OPTICALLY ACTIVE 5-THIOXOTETRAHYDRO-5<i>H</i>-OXAZOLO[3,2-<i>c</i>]PYRIMIDIN-2(3<i>H</i>)ONES

Авторы

  • Ulyana M. Aristova Самарский государственный технический университет
  • Anna V. Vologzhanina A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov St., Moscow 119334, Russia
  • Andrey K. Shiryaev Samara State Technical University, 244 Molodogvardeyskaya St., Samara 443100, Russia

DOI:

https://doi.org/10.1007/7780

Ключевые слова:

amino acid, oxazolopyrimidine, pyrimidine, diastereoselectivity, optical rotation.

Аннотация

5-Thioxotetrahydro-5H-oxazolo[3,2-c]pyrimidin-2(3H)-ones were prepared by the reaction of L- and D-amino acid esters with 4-isothiocyanato-4-methylpentan-2-one at room temperature. The configuration of products was confirmed by the comparison of optical rotary power calculated according to time-dependent DFT with experimental values and by X-ray analysis. The mechanism of the reaction has been discussed.

Биография автора

Ulyana M. Aristova, Самарский государственный технический университет

доктор химических наук, профессор, Кафедра органической химии

Загрузки

Опубликован

2023-11-01

Выпуск

Том 59 № 9/10 (2023)

Раздел

Оригинальные статьи