Condensation of N-ethylpiperid-4-one with benzaldehyde

Authors

  • Н. В. Алексеева Center for the Chemistry of Medicinal Agents, All-Russian Chemicopharmaceutical Institute, Moscow 119815
  • Л. Н. Койков Center for the Chemistry of Medicinal Agents, All-Russian Chemicopharmaceutical Institute, Moscow 119815
  • K. Ф. Турчин Center for the Chemistry of Medicinal Agents, All-Russian Chemicopharmaceutical Institute, Moscow 119815

Abstract

Reaction of N-ethylpiperid-4-one with benzaldehyde and KOH in 65% aqueous methanol gives 2,7-diethyl-10a-hydroxy-9-phenyl-4-(phenylmethylene)-2,7-diaza-10-oxa-1,2,3,4,5,6,7,8,8a,10a-decahydroanthracene. In the presence of HCl/EtOH, 3,5-bis(phenylmethylene)-1-ethylpiperid-4-one is formed. In the presence of HCl/AcOH, 2,7-diethyl-9-phenyl-4,5-bis(phenylmethylene)-2,7-diaza-10-oxa-1,2,3,4,5,6,7,8-octahydroanthracene is formed.

How to Cite
Alekseeva, N. V.; Koikov, L. N.; Turchin, K. F. Chem. Heterocycl. Compd. 1998, 34, 1070. [Khim. Geterotsikl. Soedin. 1998, 34, 1247.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02251553

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Published

1998-09-25

Issue

No. 9 (1998)

Section

Original Papers