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SYNTHESIS OF THE FIRST 13-NITROARYL DERIVATIVES OF 8-ACETONYLBERBERINE

Олег Н. Буров, Сергей В. Курбатов, Павел Г. Морозов, Михаил Е. Клецкий, Артем В. Татаров
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Abstract


For the first time a method for the synthesis of 8-acetonylberberine 13-nitroaryl derivatives has been developed comprising a one-pot reaction of berberine, acetone, and neutral aromatic electrophiles (picryl chloride, 4-chloro-7-nitrobenzofurazan, 4-chloro-5,7-dinitrobenzofurazan). It was found that the reaction of 8-acetonylberberine with these chloronitroarenes does not lead to the formation of the target compounds.

How to Cite
Burov, O. N.; Kurbatov, S. V.; Morozov, P. G.; Kletskii, M. E.; Tatarov, A. V. Chem. Heterocycl. Compd. 2015, 51, 772. [Khim. Geterotsikl. Soedin. 2015, 51, 772.]

For this article in the English edition see DOI 10.1007/s10593-015-1774-6


Keywords


berberine; nitroarene; nucleophilic aromatic substitution

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