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SYNTHESIS OF PURINE AND 2-AMINOPURINE CONJUGATES BEARING THE FRAGMENTS OF HETEROCYCLIC AMINES AT POSITION 6

Дмитрий А. Груздев, Вера В. Мусияк, Евгений Н. Чулаков, Галина Л. Левит, Виктор П. Краснов
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Abstract


A series of novel N-(purin-6-yl)- and N-(2-aminopurin-6-yl) derivatives of heterocyclic amines was synthesized. It was found that preferred preparative method for N-(purin-6-yl) derivatives of heterocyclic amines is interaction of 6-chloropurine with heterocyclic amines without any catalyst; whereas N-(2-aminopurin-6-yl) derivatives were obtained in the moderate-to-high yields while heating 2-amino-6-chloropurine and heterocyclic amines in water in the presence of sulfuric acid.

How to Cite
Gruzdev, D. A.; Musiyak, V. V.; Chulakov, E. N.; Levit, G. L.; Krasnov, V. P. Chem. Heterocycl. Compd. 2015, 51, 738. [Khim. Geterotsikl. Soedin. 2015, 51, 738.]

For this article in the English edition see DOI 10.1007/s10593-015-1767-5


Keywords


2-amino-6-chloropurine; 6-chloropurine; aromatic nucleophilic substitution; catalysis; heterocyclic amines

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