СИНТЕЗ КОНЪЮГАТОВ ПУРИНА И 2-АМИНОПУРИНА, СОДЕРЖАЩИХ В ПОЛОЖЕНИИ 6 ФРАГМЕНТЫ ГЕТЕРОЦИКЛИЧЕСКИХ АМИНОВ

Дмитрий А. Груздев; Вера В. Мусияк; Евгений Н. Чулаков; Галина Л. Левит; Виктор П. Краснов

doi:10.1007/2570

Authors

Дмитрий А. Груздев I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St., Yekaterinburg 620990
Вера В. Мусияк I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St., Yekaterinburg 620990
Евгений Н. Чулаков I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St., Yekaterinburg 620990
Галина Л. Левит I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St., Yekaterinburg 620990
Виктор П. Краснов I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St., Yekaterinburg 620990

DOI:

https://doi.org/10.1007/2570

Keywords:

2-amino-6-chloropurine, 6-chloropurine, aromatic nucleophilic substitution, catalysis, heterocyclic amines

Abstract

A series of novel N-(purin-6-yl)- and N-(2-aminopurin-6-yl) derivatives of heterocyclic amines was synthesized. It was found that preferred preparative method for N-(purin-6-yl) derivatives of heterocyclic amines is interaction of 6-chloropurine with heterocyclic amines without any catalyst; whereas N-(2-aminopurin-6-yl) derivatives were obtained in the moderate-to-high yields while heating 2-amino-6-chloropurine and heterocyclic amines in water in the presence of sulfuric acid.

How to Cite
Gruzdev, D. A.; Musiyak, V. V.; Chulakov, E. N.; Levit, G. L.; Krasnov, V. P. Chem. Heterocycl. Compd. 2015, 51, 738. [Khim. Geterotsikl. Soedin. 2015, 51, 738.]

For this article in the English edition see DOI 10.1007/s10593-015-1767-5