CONVENIENT SYNTHESIS OF 12-METHYL[1]BENZOXEPINO[3,4-b]QUINOLIN-13(6H)-ONES

Abstract

In this work, a construction of 12-methyl[1]benzoxepino[3,4-b]quinolin-13(6H)-ones, structurally intriguing hybrid molecules consisting of fused 4-methylquinoline and 1-benzoxepin-5-one units, has been successfully achieved via a two-step procedure, involving the one-pot synthesis of 2-(aryloxymethyl)-4-methylquinoline-3-carboxylic acids followed by their intramolecular Friedel–Crafts cyclization reaction. Our synthetic protocol described here could be attractive as it is simple, easy to handle and does not involve the use of expensive reagents or catalysts.