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CONVENIENT SYNTHESIS OF 12-METHYL[1]BENZOXEPINO[3,4-b]QUINOLIN-13(6H)-ONES

Yu Wang, Mingqin Chang, Hong Zhang, Yang Li
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Abstract


In this work, a construction of 12-methyl[1]benzoxepino[3,4-b]quinolin-13(6H)-ones, structurally intriguing hybrid molecules consisting of fused 4-methylquinoline and 1-benzoxepin-5-one units, has been successfully achieved via a two-step procedure, involving the one-pot synthesis of 2-(aryloxymethyl)-4-methylquinoline-3-carboxylic acids followed by their intramolecular Friedel–Crafts cyclization reaction. Our synthetic protocol described here could be attractive as it is simple, easy to handle and does not involve the use of expensive reagents or catalysts.

Keywords


1-benzoxepin-5-one; hybrid molecule; 4-methylquinoline; Friedel–Crafts cyclization; one-pot synthesis

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