CONVENIENT SYNTHESIS OF 12-METHYL[1]BENZOXEPINO[3,4-<i>b</i>]QUINOLIN-13(6<i>H</i>)-ONES

Authors

  • Yu Wang Institute of Superfine Chemicals, Bohai University, Jinzhou 121000
  • Mingqin Chang Institute of Superfine Chemicals, Bohai University, Jinzhou 121000
  • Hong Zhang Institute of Superfine Chemicals, Bohai University, Jinzhou 121000
  • Yang Li Institute of Superfine Chemicals, Bohai University, Jinzhou 121000

DOI:

https://doi.org/10.1007/4387

Keywords:

1-benzoxepin-5-one, hybrid molecule, 4-methylquinoline, Friedel–Crafts cyclization, one-pot synthesis

Abstract

In this work, a construction of 12-methyl[1]benzoxepino[3,4-b]quinolin-13(6H)-ones, structurally intriguing hybrid molecules consisting of fused 4-methylquinoline and 1-benzoxepin-5-one units, has been successfully achieved via a two-step procedure, involving the one-pot synthesis of 2-(aryloxymethyl)-4-methylquinoline-3-carboxylic acids followed by their intramolecular Friedel–Crafts cyclization reaction. Our synthetic protocol described here could be attractive as it is simple, easy to handle and does not involve the use of expensive reagents or catalysts.

Author Biographies

Yu Wang, Institute of Superfine Chemicals, Bohai University, Jinzhou 121000

Institute of Superfine Chemicals

Mingqin Chang, Institute of Superfine Chemicals, Bohai University, Jinzhou 121000

Institute of Superfine Chemicals

Hong Zhang, Institute of Superfine Chemicals, Bohai University, Jinzhou 121000

Institute of Superfine Chemicals

Yang Li, Institute of Superfine Chemicals, Bohai University, Jinzhou 121000

Institute of Superfine Chemicals

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Published

2018-07-26

Issue

Vol. 54 No. 6 (2018)

Section

Original Papers