CONVENIENT SYNTHESIS OF 12-METHYL[1]BENZOXEPINO[3,4-<i>b</i>]QUINOLIN-13(6<i>H</i>)-ONES

Авторы

  • Yu Wang Institute of Superfine Chemicals, Bohai University, Jinzhou 121000
  • Mingqin Chang Institute of Superfine Chemicals, Bohai University, Jinzhou 121000
  • Hong Zhang Institute of Superfine Chemicals, Bohai University, Jinzhou 121000
  • Yang Li Institute of Superfine Chemicals, Bohai University, Jinzhou 121000

DOI:

https://doi.org/10.1007/4387

Ключевые слова:

1-benzoxepin-5-one, hybrid molecule, 4-methylquinoline, Friedel–Crafts cyclization, one-pot synthesis

Аннотация

In this work, a construction of 12-methyl[1]benzoxepino[3,4-b]quinolin-13(6H)-ones, structurally intriguing hybrid molecules consisting of fused 4-methylquinoline and 1-benzoxepin-5-one units, has been successfully achieved via a two-step procedure, involving the one-pot synthesis of 2-(aryloxymethyl)-4-methylquinoline-3-carboxylic acids followed by their intramolecular Friedel–Crafts cyclization reaction. Our synthetic protocol described here could be attractive as it is simple, easy to handle and does not involve the use of expensive reagents or catalysts.

Биографии авторов

Yu Wang, Institute of Superfine Chemicals, Bohai University, Jinzhou 121000

Institute of Superfine Chemicals

Mingqin Chang, Institute of Superfine Chemicals, Bohai University, Jinzhou 121000

Institute of Superfine Chemicals

Hong Zhang, Institute of Superfine Chemicals, Bohai University, Jinzhou 121000

Institute of Superfine Chemicals

Yang Li, Institute of Superfine Chemicals, Bohai University, Jinzhou 121000

Institute of Superfine Chemicals

Загрузки

Опубликован

2018-07-26

Выпуск

Том 54 № 6 (2018)

Раздел

Оригинальные статьи