

ANNULATION OF TETRAHYDRO-2-PYRIMIDINONE WITH α-IODO KETONES

Abstract
The first annulated heterocyclic derivatives of tetrahydro-2-pyrimidin-2(1H)-one were synthesized in one preparative step on the basis of a solventless three-component reaction of tetrahydro-2-pyrimidin-2(1H)-one with 1-iodopropan-2-one, 2-iodo-1-phenylethan-1-one, 2iodo-1-(thiophen-2-yl)ethan-1-one, or 1,3-diiodopropan-2-one and elemental iodine in the absence of a base.
Authors:
Ivan А. Dorofeev, Ludmila G. Shagun, Larisa V. Zhilitskaya,
Nina O. Yarosh, Ludmila I. Larina
Keywords
1,3-diiodopropan-2-one; 6-hydroxy-1,5-diazabicyclo[3.2.1]octan-8-one; 2-iodo-1-phenylethan-1-one; 1-iodopropan-2-one; 2iodo-1-(thiophen-2-yl)ethan-1-one; tetrahydro-2-pyrimidin-2(1Н)-one; alkylation; annulation.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv